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Polypharmacy in Treatment-Resistant Depression
Scenario
A 46-year-old male with depression was prescribed fluoxetine, bupropion, and alprazolam for sleep. He reported poor sleep and persistent depressive symptoms.
Challenge
Simplifying therapy and improving efficacy.
Pharmacist Intervention
Pharmacist suggested tapering alprazolam and starting mirtazapine for its sedative properties and antidepressant effects.
Outcome
Improved sleep and depressive symptoms with a simplified regimen.
Lesson
Simplifying regimens can improve outcomes and reduce risks associated with polypharmacy.



